Table 1. Potency of MN58b and JAS239 in a panel of breast cancer cell lines.

	IC50 (μM)		EC50 (μM)
Cell Line	MN58b	JAS239	MN58b	JAS239
MCF7-EV	3.85 ± 0.42	11.1 ± 5.64	3.29 ± 0.48	4.04 ± 0.55
MCF7-CK+	2.36 ± 0.28	10.3 ± 2.48	6.86 ± 0.43	5.33 ± 0.84
MDA-MB-231	4.36 ± 1.37	9.92 ± 0.22	14.26 ± 4.6	27.2 ± 7.9
4175-Luc+	4.59 ± 0.55	9.89 ± 0.24	20.7 ± 6.4	35.0 ± 21.6

Cells were treated with varying concentrations of MN58b or JAS239 and analyzed after 2 h for ¹⁴C-PC production or after 17 h for cell viability. Data for 3 separate experiments were fitted to sigmoidal plots and IC₅₀s and EC₅₀s are reported ± SEM for the radiotracing and viability assays, respectively.