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. 2016 Dec 27;8(10):16669–16689. doi: 10.18632/oncotarget.14291

Figure 7. Reversine and SP600125 inhibit diploid MFH152 clone invasion in 3D.

Figure 7

(A) and (B) A diploid MFH152 clone was used to generate spheroids. Spheroids were transferred in collagen matrix (Panel A, 0 h) to allow invasion. Drug dilution buffer (Control) or Reversine or SP600125 were added to the collagen matrix and spheroids were imaged using time-lapse microscopy for up to 24 h to evaluate the drug effects on invasion. Panel (A) displays the fate of a single spheroid in the control and treatment conditions, at 0, 6, 12, 18 h while quantitative data of invasion are represented in panel (B).