Table 1. Overview of the SCC included in the study, their diagnosis, the fusion transcripts tested for each of them, the HPV status, and the immunohistochemistry data.
| Case/lab number | Diagnosis | Fusion transcripts tested | Chromosomal location gene 1-gene 2 | HPV genotyping | Immunohistochemistry score |
|---|---|---|---|---|---|
| 1/02-91 | SCC moderately differentiated |
PPFIA1-AHNAKIRF6-C1orf74 IRF6-C1orf74 STIP1-CREB3L1 CELF1-DDIAS |
11q13.3-11q12.3 1q32.2-1q32.2 11q13.1-11p11.2 11p11.2-11q14.1 |
− | 3 |
| 2/02-167 | SCC moderately differentiated |
ZDHHC5-GPR137 IRF6-C1orf74 RBM4-SIPA1 |
11q12.1-11q13.1 1q32.2-1q32.2 11q13.2-11q13.1 |
− | 2 |
| 3/02-848 | SCC moderately differentiated |
WNK1-B4GALNT3 IRF6-C1orf74 |
12p13.33-12p13.33 1q32.2-1q32.2 |
− | 0 |
| 4/02-869 | SCC* |
IRF6-C1orf74 ADCK4-NUMBL |
1q32.2-1q32.2 19q13.2-19q13.2 |
− | 1 |
| 5/03-830 | SCC moderately differentiated |
ADCK4-NUMBL IRF6-C1orf74 MFSD3-LRRC14 |
19q13.2-19q13.2 1q32.2-1q32.2 8q24.3-8q24.3 |
− | 1 |
| 6/03-1011 | SCC* |
IRF6-C1orf74 ADCK4-NUMBL |
1q32.2-1q32.2 19q13.2-19q13.2 |
− | 2 |
| 7/03-1088 | SCC well differentiated | IRF6-C1orf74 | 1q32.2-1q32.2 | n.a.** | — |
| 8/006-19 | SCC poorly differentiated | IRF6-C1orf74 | 1q32.2-1q32.2 | − | 2 |
| 9/06-125 | SCC moderately differentiated | -- | − | 1 | |
| 10/06-709 | SCC moderately differentiated | IRF6-C1orf74 | 1q32.2-1q32.2 | HPV 16 | 3 |
| 11/09-0733 | SCC well differentiated | DDX5-POLG2IRF6-C1orf74 | 17q23.3-17q23.3 1q32.2-1q32.2 |
− | 1 |
| 12/09-818 | SCC moderately differentiated |
PLCB3-BAD IRF6-C1orf74 PARP12-SLC37A3 |
11q13.1-11q13.1 1q32.2-1q32.2 7q34-7q34 |
− | 0 |
*information on grade is not available.
**n.a.= not available.