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. 2017 Jan 25;8(10):16912–16924. doi: 10.18632/oncotarget.14818

Figure 1. MHY2013 is the strongest PPAR pan agonist among six newly synthesized compounds.

Figure 1

For luciferase assays to screen of six newly synthesized compounds for PPAR pan agonist, the 3X-PPRE-TK-LUC plasmid and respective PPAR subtype expression vectors were transfected in YPEN-1 cells. Twenty-four hours after the transfection, the cells were treated with the indicated new compounds or respective PPAR agonists (WY14643, GW501516 or rosiglitazone) for 5 h. The data are shown as the mean ± SEM (n = 4) luciferase activity, considered to represent the PPAR transcriptional activity. *, p < 0.05 vs. DMSO control (CON); **, p < 0.01 vs. CON; ***, p < 0.001 vs. CON; #, p < 0.05 vs. WY14643, GW501516 or rosiglitazone; ##, p < 0.01 vs. WY14643, GW501516 or rosiglitazone; ###, p < 0.001 vs. WY14643, GW501516 or rosiglitazone.