Figure 4. FOXM1 regulates PSA enhancer/promoter activity in the presence or absence of androgen.

LNCaP and C4-2 cells were co-transfected with PSA enhancer/promoter together with FOXM1 cDNA or FOXM1 siRNA at set doses for 48 hours. The cells were treated with 10 nM R1881 for an additional 16 hours. Luciferase activity was tested and renilla activity used as the transfection control. n = 4, **P < 0.01. (A) LNCaP cells. (B) C4-2 cells.