Table 1. Characteristics of studies included in meta-analysis of surgical margin status and bladder cancer outcomes.
| Study | Country/Type | Period | Mean follow -up(months) | Mean age | Sample-size | Positive SM(%) | Positive LN(%) | T stage(%) |
|---|---|---|---|---|---|---|---|---|
| Soave 2015 [21] | Germany; single-center study | 1996-2011 | 45.0 | 67.0 | 517 | 12.0 | 26.7 | ≤T2:55.5; ≥T3:44.5 |
| Satkunasivam 2015 [10] | USA; single-center study | 1971-2009 | 148.8 | 66.2 | 2047 | 0.0 | NA | ≤T2:63.3; ≥T3:36.7 |
| Reder 2015 [8] | USA; single-center study | 2000-2012 | 20.0 | 67.9 | 364 | 10.7 | 20.0 | ≤T2:54.1; ≥T3:44.5 |
| Raza 2015 [34] | International multicenter study | 2003-2015 | 67.0 | 69.0 | 702 | 8.0 | 21.0 | ≤T2:62.0; ≥T3:38.0 |
| Kanatani 2015 [29] | Japan; single-center study | 1990-2012 | 29.0 | 64.0 | 61 | 11.5 | 50.8 | ≤T2:13.1; ≥T3:86.9 |
| Gakis 2015 [35] | International multicenter study | 1994-2011 | 64.0 | 54.0 | 297 | 2.4 | 20.2 | ≤T2:40.4; ≥T3:59.6 |
| Booth 2015 [11] | Canada; single-center study | 1994-2008 | NA | 72.0 | 2802 | 13.0 | 29.0 | ≤T2:29.0; ≥T3:71.0 |
| Aziz 2015 [36] | International multicenter study | 1989-2011 | 40.0 | 68.0 | 856 | 24.8 | 53.6 | ≤T2:0.0; ≥T3:100.0 |
| Albisinni 2015 [22] | International multicenter study | 2000-2013 | 50.0 | 68.0 | 503 | 5.8 | 23.1 | ≤T2:57.9; ≥T3:42.1 |
| Yuh 2014 [12] | USA; single-center study | 2004-2012 | 52.0 | 70.0 | 162 | 4.3 | 21.6 | ≤T2:66.7; ≥T3:33.3 |
| Suer 2014 [30] | Turkey; single-center study | 1990-2012 | 37.7 | 66.5 | 290 | 7.6 | 14.5 | ≤T2:54.8; ≥T3:45.2 |
| Sejima 2014 [31] | Japan; single-center study | 2003-2011 | 24.8 | 71.1 | 249 | 4.4 | 15.7 | ≤T2:56.6; ≥T3:43.4 |
| Ploussard 2014 [37] | International multicenter study | 1979-2012 | 32.2 | 68.0 | 8141 | 23.7 | 23.7 | ≤T2:56.8; ≥T3:43.2 |
| Nieuwenhuijzen 2014 [23] | Netherlands; single-center study | 1990-2006 | 64.0 | 62.3 | 343 | 10.0 | 34.0 | ≤T2:52.0; ≥T3:48.0 |
| May 2014 [24] | International multicenter study | 1989-2008 | 36.0 | 67.0 | 385 | 22.3 | 51.4 | ≤T2:0.0; ≥T3:100.0 |
| Lin 2014 [12] | USA; single-center study | 1990-2010 | 66.0 | 68.0 | 196 | 0.0 | NA | ≤T2:100.0; ≥T3:0.0 |
| Kluth 2014 [38] | International multicenter study | 1998-2010 | 36.1 | 67.0 | 2895 | 5.5 | 26.9 | ≤T2:53.9; ≥T3:46.1 |
| Klatte 2014 [39] | International multicenter study | 1979-2012 | 41.0 | 67.5 | 7906 | 5.3 | 23.8 | ≤T2:58.1; ≥T3:41.9 |
| Bruins 2014 [25] | Netherlands; single-center study | 1998-2011 | 75.6 | 65.0 | 245 | 2.9 | NA | ≤T2:64.9; ≥T3:35.1 |
| Bachir 2014 [14] | Canada; multicenter study | 1998-2008 | 39.0 | 65.6 | 847 | 10.6 | 22.4 | ≤T2:49.8; ≥T3:50.2 |
| Lotan 2013 [9] | USA; single-center study | 2007-2012 | 20.0 | 70.0 | 216 | 7.0 | 25.0 | ≤T2:60.0; ≥T3:40.0 |
| Fritsche 2013 [26] | Germany; multicenter study | 2006-2010 | 20.0 | 69.0 | 158 | 26.6 | 100.0 | ≤T2:19.6; ≥T3:80.4 |
| Todenhofer 2012 [27] | Germany; single-center study | 1999-2010 | 30.0 | 67.8 | 258 | 10.1 | 27.1 | ≤T2:50.4; ≥T3:49.6 |
| Mitra 2012 [15] | USA; single-center study | 1971-2005 | 31.2 | 62.3 | 447 | 7.8 | 48.8 | ≤T2:26.6; ≥T3:24.6 |
| Gondo 2012 [32] | Japan; single-center study | 2000-2009 | 26.8 | 68.0 | 194 | 10.3 | 10.8 | ≤T2:55.7; ≥T3:44.3 |
| Yafi 2011 [16] | Canada; multicenter study | 1998-2008 | 35.0 | 68.0 | 2287 | 8.6 | 25.9 | ≤T2:48.1; ≥T3:51.9 |
| Sonpavde 2011 [40] | International multicenter study | 1971-2008 | 39.4 | 68.5 | 578 | 4.0 | 0.0 | ≤T2:0.0; ≥T3:100.0 |
| Hofner 2011 [28] | Germany; single-center study | 1990-2009 | 104.4 | 64.0 | 328 | 17.0 | 36.0 | ≤T2:49.0; ≥T3:51.0 |
| Tilki 2010 [41] | International multicenter study | 1979-2008 | 55.0 | 68.9 | 583 | 24.9 | 53.5 | ≤T2:0.0; ≥T3:100.0 |
| Kim 2010 [33] | Korea; single-center study | 1986-2005 | 66.3 | 60.8 | 406 | 3.9 | 12.1 | ≤T2:67.2; ≥T3:32.8 |
| Fairey 2009 [17] | Canada; single-center study | 1994-2007 | 31.0 | 66.0 | 523 | 12.0 | 23.0 | ≤T2:49.0; ≥T3:51.0 |
| Chapman 2009 [18] | USA; single-center study | 1996-2006 | 34.3 | 66.4 | 308 | 12.7 | 27.3 | ≤T2:49.0; ≥T3:51.0 |
| Canter 2009 [19] | USA; single-center study | 1988-2006 | 46.4 | 65.5 | 344 | 11.6 | NA | ≤T2:89.0; ≥T3:11.0 |
| Dotan 2007 [4] | USA; single-center study | 1985-2005 | NA | 65.9 | 1589 | 4.2 | 24.0 | ≤T2:54.0; ≥T3:46.0 |
| Lee 2006 [7] | Korea; single-center study | 1995-2002 | 37.1 | 61.0 | 115 | 4.3 | 0.0 | NA |
| Herr 2004 [20] | USA; multicenter study | 1987-1998 | 106.8 | 64.6 | 242 | 10.0 | 20.5 | ≤T2:69.0; ≥T3:31.0 |
Abbreviations: SM, surgical margin; LN, lymph node; NA, data not applicable