Table 1. Compensatory changes in CYP gene expression in CAR-null mice.

	MALES		FEMALES
Gene	WT#	CAR-null	WT	CAR-null
Cyp2a4	1.00 ± 0.241	5.276 ± 0.904	13.983 ± 0.762c	15.241 ± 3.940b
Cyp2b9	1.00 ± 0.353	0.424 ± 0.096	18.35 + 2.898c	0.151 ± 0.063b
Cyp2b10	1.00 ± 0.692	0.196 ± 0.027	10.186 ± 2.249c	0.054 ± 0.011b
Cyp2b13	1.00 ± 0.312	0.021 ± 0.006	4.139 ± 0.798c	0.009 ± 0.004b
Cyp2c29	1.00 ± 0.251	0.395 ± 0.388	0.306 ± 0.091	0.188 ± 0.082
Cyp2c40	1.00 ± 0.950	0.805 ± 0.753	6.992 ± 0.551c	3.174 ± 0.936b
Cyp3a11	1.00 ± 0.341	0.461 ± 0.085	1.805 ± 0.283c	0.904 ± 0.176b
Cyp3a41	1.00 ± 0.475	430.0 + 405.8	81.01 + 33.43c	442.0 + 178.9

#Data are presented as relative mean ± SEM. Statistical significance determined by ANOVA followed by Fisher’s LSD as the post-hoc test (n = 5–6).

‘b’ indicates WT females different than CAR-null females.

‘c’ indicates WT males different than WT females.

Letter with no asterisk indicates a p-value < 0.05