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. 2017 Mar 28;12(3):e0174355. doi: 10.1371/journal.pone.0174355

Table 3. Compensatory changes in CYP gene expression in Cyp2b9/10/13-null mice.

	MALES		FEMALES
Gene	WT^#	Cyp2b9/10/13-null	WT	Cyp2b9/10/13-null
Cyp2a4	1.00 ± 0.187	5.162 ± 3.948	18.864±4.066^c ^*	7.217 ± 2.294^b
Cyp2b9	1.00 ± 0.692	0.054 ± 0.018	3.007 ± 0.897^c	0.047 ± 0.020^b ^*
Cyp2b10	1.00 ± 0.655	0.041 ± 0.014	2.274 ± 0.678	0.035 ± 0.015^b ^*
Cyp2b13	1.00 ± 0.709	0.059 ± 0.048	36.189 ± 7.478^c ^***	0.082± 0.078^b ^**
Cyp2c29	1.00 ± 0.091	2.277 ± 0.760	0.628 ± 0.123	1.472 ± 0.792
Cyp2c40	1.00 ± 0.123	0.911 ± 0.636	5.202 ± 2.169^c	1.620 ± 0.846^b
Cyp3a11	1.00 ± 0.124	0.790 ± 0.173	0.828 ± 0.101	0.524 ± 0.045
Cyp3a13	1.00 ± 0.170	0.551 ± 0.114	1.088 ± 0.121	0.536 ± 0.077^b
Cyp3a25	1.00 ± 0.346	0.983 ± 0.350	0.991 ± 0.083	0.515 ± 0.126
Cyp3a41	1.00 ± 0.756	0.112 ± 0.107	19.459 ± 5.931^c ^*	11.168 ± 1.627^d

^#Data represented as mean +/- SEM (n = 4). Statistical significance determined by one-way ANOVA followed by LSD as the post-hoc test.

‘b’ indicates WT females different than Cyp2b9/10/13-null females.

‘c’ indicates WT males different than WT females.

‘d’ indicates Cyp2b9/10/13-null males different than Cyp2b9/10/13-null females.

Letter with no asterisk indicates a p-value < 0.05 and

* indicates a p-value < 0.01,

** indicates a p-value <0.001,

***indicates a p-value <0.00001