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Suppression of FAK phosphorylation reduces TGFβ-induced migration and invasion of bladder cancer cells.
Notes: T24 and 5637 cells were treated with 5 ng/mL TGFβ and 10 μM PF-228. (A and B) Expression of Src, pSrc, FAK and pFAK was examined by Western blotting. (C) Cell invasion and migration were measured by Transwell assays. Scale bar, 200 μm.
Abbreviations: FAK, focal adhesion kinase; TGFβ, transforming growth factor beta.
