Fig 5. Connectivity map (CMAP) pathway and network analysis for AR-A014418 target genes.

Gene list generated to obtain the drug profiles for AR-A014418 (S6 Table) was utilized to compile the CMAP “AR-A014418” target-gene list, and genes prospectively up-regulated are presented as a heatmap in (A) showing enrichment in earlier postnatal dorsal subventricular zone (dSVZ) cells. aEPs, adult ependymas; aNPs, adult neuronal precursors; GM, grey matter; astros, astrocytes; mOLs, mature/myelinating oligodendrocytes; aNSCs, adult neural stem cells (NSCs); dNSCs, dorsal NSCs; dTAPs, dorsal transient amplifying progenitors (TAPs); lNSCs, lateral NSCs; lTAPs, lateral TAPs. (B) Prospectively up-regulated or down-regulated genes analyzed by Genego Metacore for GO Pathway Maps and Process Networks, and lists are ranked according to significance (false discovery rate [FDR] <1%)/numbers of genes present in each of the categories. (C, D) Short path network to visualize highly connected signaling-to-transcriptional nodes were performed for up- and down-regulated ARA-014418 target genes. Internal clusters were grouped by selecting the “link GO objects” in GeneGo Metacore. Highlighted blue objects are directly within data and remaining objects are within the background (or basal) data.