Fig 2. Models of the last heptad of ΔMax and WT Max.

Models of the last heptad of the LZ of ΔMax (A) and WT Max (B) in a homodimeric state. Models of the last heptad of the LZs of ΔMax/c-Myc (C), WT Max/c-Myc (D) and ΔMax/WT Max (E) in a heterodimeric state. Although various structures of the Max homodimeric and c-Myc/Max b-HLH-LZ have been reported [16,17], the last heptad is incomplete or ill-defined in all of them. They were therefore remodeled along with the LZ of ΔMax using the program Pymol (http://www.pymol.org) and the backbone of the structure of the heterodimeric c-Myc/Max (1A93) as a template [18].