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. 2017 Mar 28;12(3):e0174413. doi: 10.1371/journal.pone.0174413

Fig 4. In solution with c-Myc*, Max* forms both homo- and heterodimers while ΔMax* exclusively heterodimerizes.

Fig 4

(A) Far-UV CD spectra of c-Myc* (open circles), Max* (open diamonds), c-Myc*/Max* (black circles) and the arithmetic sum of the individual spectra (gray circles). (B) Thermal denaturation of c-Myc*/Max* (black circles) recorded by monitoring the CD signal at 222 nm. The melting temperatures (T°) of the complexes of the mixture are indicated by the dotted lines. (C) Far-UV CD spectra of c-Myc* (open circles), ΔMax* (open triangles), c-Myc*/ΔMax* (black triangles) and the arithmetic sum of the individual spectra (gray triangles). (D) Thermal denaturation of c-Myc*/ΔMax* (black triangles) recorded by monitoring the CD signal at 222 nm and simulation of the thermal denaturation of an 8 μM dimer into two unfolded monomers (open circles). The melting temperature (T°) is indicated by the dotted line.