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. 2017 Mar 28;12(3):e0174413. doi: 10.1371/journal.pone.0174413

Fig 7. The c-Myc*/ΔMax* heterodimer binds E-Box and non-specific DNA sequences with similar apparent affinities.

Fig 7

(A) Titration of fluorescently labeled E-box (black circles) and non-specific (open circles) sequences with 1:1 mixtures of c-Myc*/ΔMax*. (B) Populations of ΔMax*/Max* (blue), ΔMax*/c-Myc* (red) and ΔMax*/ΔMax* (pale blue) with the E-box (full lines) and the non-specific (dotted lines) sequences as a function of the total dimeric concentrations. (C) Titration of fluorescently labeled E-box (black circles) and non-specific (open circles) sequences with a 1:1 mixture of c-Myc*/Max. The lines were obtained from the simulation of the binding of 3 species: (D) c-Myc*/Max* (purple), Max*/Max* (blue) and c-Myc*/c-Myc* (red) for the E-box (full lines) and non-specific (dotted lines) sequences.