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Glutamate released from presynaptic terminals binds to postsynaptic glutamate receptors and activates ADAMs in neurons (e.g., ADAM17) via PKC. ADAMs then cleave the ectodomain of the NRG1 type II precursor and liberates mature NRG1 type II. Free NRG1 type II binds ErbB4 receptors in neurons or neighboring neurons, presumably leading to glutamatergic development, maturation, or both.
