Table 3. Time-dependent analysis.
| Dose: 6.7 Gy | Dose: 7.4 Gy | |||
|---|---|---|---|---|
| Pathway | p-value | Overlap | p-value | Overlap |
| Acute Phase Response Signaling | 4.98E-23 | 14/169 | 9.97E-15 | 10/169 |
| Clathrin-mediated Endocytosis Signaling | 9.82E-11 | 8/197 | 1.99E-07 | 6/197 |
| Coagulation System | 5.41E-17 | 8/35 | 4.97E-12 | 6/35 |
| Extrinsic Prothrombin Activation Pathway | 4.53E-09 | 4/16 | ||
| FXR/RXR Activation | 2.68E-12 | 8/126 | ||
| Intrinsic Prothrombin Activation Pathway | 1.46E-12 | 6/29 | ||
| LXR/RXR Activation | 1.93E-12 | 8/121 | ||
The top 5 canonical pathways identified by IPA from proteins significantly differentiating between days 4, 7, and 12 post-irradiation. The pathway p-values are calculated using the right-tailed Fisher Exact Test. The complete list of pathways can be found in S3 Table.