Table 4. Dose-dependent analysis.
| Day 4 | Day 7 | Day 12 | ||||
|---|---|---|---|---|---|---|
| Pathway | p-value | Overlap | p-value | Overlap | p-value | Overlap |
| Actin Cytoskeleton Signaling | 1.29E-10 | 9/228 | ||||
| Acute Phase Response Signaling | 1.83E-14 | 8/169 | 1.83E-13 | 10/169 | 8.10E-18 | 11/169 |
| Clathrin-mediated Endocytosis Signaling | 3.38E-13 | 9/197 | ||||
| Coagulation System | 1.21E-11 | 5/35 | 1.51E-13 | 7/35 | 3.12E-10 | 5/35 |
| Extrinsic Prothrombin Activation Pathway | 1.03E-07 | 3/16 | 1.96E-09 | 4/16 | ||
| FXR/RXR Activation | 6.13E-13 | 9/126 | ||||
| Intrinsic Prothrombin Activation Pathway | 2.07E-09 | 4/29 | ||||
| LXR/RXR Activation | 7.17E-07 | 4/121 | 4.23E-13 | 9/121 | 3.98E-11 | 7/121 |
The top 5 canonical pathways identified by IPA from proteins significantly differentiating between 6.7 Gy and 7.4 Gy gamma-irradiation dose levels. The pathway p-values are calculated using the right-tailed Fisher Exact Test.