Table 2.

Conditional/stepwise regression models to test for additional independent BP SNPs at each locus. Effect sizes (mmHg) and P-values are given from a univariate fit of each SNP one-at-a-time (univariate) and a joint fit of all of the SNPs at each locus (joint).

(a) SNPs discovered in GERA. The SNPs on chromosome 20 show an independent phenotype trait association for different SNPs. Rs2104574 is the lead GERA SNP near a previously-identified SNP.
					GERA Meta-analysis (n=99,785)				UKB Meta-analysis (n=152,081)				GERA + UKB Meta-analysis (n=251,866)
					Univariate		Joint		Univariate		Joint		Univariate		Joint
Chr	Trait	SNP	Position	Allele	Eff	P	Eff	P	Eff	P	Eff	P	Eff	P	Eff	P
6	PP	rs1322640	169586887	T/C	−0.27	8.9×10−11	−0.28	4.7×10−11	−0.40	4.0×10−13	−0.41	1.3×10−13	−0.32	1.1×10−21	−0.33	2.1×10−22
		rs13197550	169716025	C/A	−0.23	2.1×10−9	−0.23	1.4×10−9	−0.20	2.3×10−5	−0.21	8.3×10−6	−0.22	2.5×10−13	−0.22	5.8×10−14
20	PP	rs2104574	10968891	C/T	−0.10	0.012	−0.091	0.024	−0.18	0.00025	−0.18	0.0005	−0.13	2.2×10−5	−0.12	8.3×10−5
		20:10573001:I	10573001	C/CG	0.45	6.2×10−9	0.44	1.0×10−8	0.24	0.012	0.22	0.023	0.37	1.1×10−9	0.36	3.8×10−9
20	DBP	rs2104574	10968891	C/T	−0.25	2.6×10−10	−0.25	2.4×10−10	−0.21	2.2×10−7	−0.22	7.1×10−8	−0.23	4.0×10−16	−0.23	1.1×10−16
		20:10573001:I	10573001	C/CG	0.0026	0.97	−0.015	0.84	−0.25	0.00089	−0.28	0.00024	−0.12	0.021	−0.15	0.0067

(b) SNPs discovered in the GERA and UKB meta-analysis. The SNP rs12770529 on chromosome 10 was associated with DBP.
					GERA Meta-analysis (n=99,785)				UKB Meta-analysis (n=152,081)				GERA + UKB Meta-analysis (n=251,866)
					Univariate		Joint		Univariate		Joint		Univariate		Joint
Chr	Trait	SNP	Position	Allele	Eff	P	Eff	P	Eff	P	Eff	P	Eff	P	Eff	P
2	PP	rs13403122	43078758	C/T	0.22	1.3×10−7	0.21	4.5×10−7	0.16	8e-05	0.15	0.00018	0.19	7.2×10−11	0.18	5.2×10−10
		rs2115859	43386092	T/C	0.17	3.1×10−6	0.17	9.9×10−6	0.14	0.00027	0.13	0.0006	0.16	4.1×10−9	0.15	2.7×10−8
3	PP	rs149240564	41867621	A/G	0.39	1.6×10−7	−0.048	0.62	0.76	3.3×10−32	0.77	1.9×10−31	0.60	3.9×10−35	0.51	1.4×10−20
		rs9816560	41872527	G/T	0.43	2e×10−19	0.45	7.5×10−13	0.30	0.19	−0.26	0.29	0.43	9.8×10−20	0.41	2.1×10−11
6	PP	rs147384090	32013850	C/T	−0.90	0.18	−0.92	0.17	−0.29	1.3×10−16	−0.29	1.7×10−16	−0.29	7.7×10−17	−0.29	1.0×10−16
		rs3129927	32333827	C/A	0.23	0.00061	0.23	0.00059	0.35	5.4×10−7	0.34	7.3×10−7	0.29	2.6×10−9	0.29	3.2×10−9
10	PP	10:104957628:D	104957628	AT/A	0.61	1.2×10−17	0.61	2.1×10−17	1.6	0.073	1.6	0.071	0.62	4.5×10−18	0.62	7.7×10−18
		rs12770529	105149645	C/T	−0.02	0.71	0.032	0.55	0.062	0.36	0.066	0.33	0.012	0.78	0.046	0.28

Chr, chromosome; Position, b37 position; Eff, effect.