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. 2016 Dec 20;97(6):412–421. doi: 10.1111/iep.12212

Figure 4.

Figure 4

Downregulation of methylation of the ABCB1 gene decreased the DDP resistance in A549 lung adenocarcinoma cell lines. (a) After 5‐Aza‐C treatment for 24 and 48 h, inhibition of A549 cell viability was analysed using CCK‐8 assay. (b) CCK‐8 assay was used to detect A549 cell proliferation after 5‐Aza‐C treatment. (c) EdU assay was used to detect A549 cell proliferation after 5‐Aza‐C treatment. (d) Representative apoptosis assay using flow cytometry, A549 and A549/DDP cells. (e) Hoechst staining of apoptosis. *P < 0.05. **P < 0.01.