Table 1.
Concentrations of DDP used at each selection dose
| Dose | DDP |
|---|---|
| IC50 | 7.20 μg/ml |
| Dose 1 | 7.20 pg/ml |
| Dose 2 | 21.6 pg/ml |
| Dose 3 | 64.8 pg/ml |
| Dose 4 | 194.4 pg/ml |
| Dose 5 | 583.2 pg/ml |
| Dose 6 | 1.75 μg/ml |
| Dose 7 | 5.25 μg/ml |
| Dose 8 | 15.75 μg/ml |
| Dose 9 | 23.63 μg/ml |
| Dose 10 | 35.44 μg/ml |
| Dose 11 | 53.16 μg/ml |
| Dose 12* | 79.73 μg/ml |
A549 human lung adenocarcinoma cells were exposed to progressively higher concentrations (doses) of DDP drugs. The initial dose was equivalent to 1/1000th of the concentration required to kill or inhibit the growth of 50% of wild‐type A549 cultured human lung adenocarcinoma cells (the IC50). The symbol *denotes the highest concentration of DDP allowing for cell survival (the maximally tolerated dose).