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The histopathology of cartilage assessment. The cartilage histopathology was measured from articular cartilage of the tibia by Safranin-O stain (A). The surface damage (B), the loss of cellularity (C), the loss of matrix stain (D) and the loss of tidemark integrity were measured. *P < 0.05, **P < 0.001 compared to sham group. #P < 0.05, ## P < 0.001 compared to OA group. ※P< 0.05 compared to T(M) group. All rats were n = 8.
