Table I.
Composition of various optimized dermatological bases containing 1% w/w norfloxacin and metronidazole, respectively
| Dermatological base | ||||
|---|---|---|---|---|
| Ingredients | Carbopol base (g) | HPMC base (g) | PEG base (g) | Ointment base (g) |
| Norfloxacin (NF) | 1.0 | 1.0 | 1.0 | 1.0 |
| Metronidazole (MTZ) | 1.0 | 1.0 | 1.0 | 1.0 |
| Carbopol gel base | 98.0 | – | – | – |
| Propylene glycol | – | – | – | – |
| Methyl paraben | – | 0.3 | – | – |
| Ethyl paraben | – | 0.2 | – | 10.0 |
| HPMC gel base | – | 2.0 | – | – |
| PEG 4000 | – | – | 53.0 | – |
| PEG 300 | – | – | 45.0 | – |
| DMSO | – | – | – | 10.5 v/w |
| Isopropyl myristate | – | – | – | 10.0 v/w |
| Mineral oil | – | – | – | 30.0 v/w |
| White petrolatum | – | – | – | 30.7 v/w |
| Bees wax | – | – | – | 5.8 v/w |
| Glycerine | – | 10.0 | – | – |
| Water | – | Quantity sufficient | – | 1.0 v/w |