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Physicochemical properties of topical formulations
| Formulation base | pHa | Apparent viscositya (cPs) | Spreadabilitya (s) | Extrudabilitya (g) |
|---|---|---|---|---|
| Carbopol | 7.1 ± 1.2 | 11 × 106 | 27 ± 1.5 | 505 ± 1.3 |
| PEG | 7.0 ± 0.7 | 29 × 106 | 35 ± 0.6 | 515 ± 0.4 |
| HPMC | 6.0 ± 1.5 | 47 × 106 | 49 ± 0.4 | 572 ± 0.7 |
| Ointment | 6.8 ± 0.9 | 28 × 106 | 37 ± 0.2 | 592 ± 0.5 |
Average of three determinations
