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. 2016 Jun 30;8(2):68–76. doi: 10.1556/1646.8.2016.2.4

Table VIII.

Comparative observation of morphological changes in histopathological study of selected norfloxacin–metronidazole topical formulations with Silver Sulfadiazine 1% cream, USP

Days NF–MTZ Carbopol formulation Silver Sulfadiazine 1% cream, USP (SS)
Day 1 Prominent ulceration with diffuse burns on the skin and subcutaneous tissue, evidence of coagulative necrosis Presence of ulcer on surface due to injury, covered with slough and necrotic debris
Day 4 Beginning of granulation tissue formation with reepithelialization, moderate scab formation, good proliferation, numerous inflammatory macrophages and fibroblasts seen Adequate scab formed, beneath which a clot composed of fibrin, RBCs and platelets are formed. Inflammatory cells like macrophages and neutrophils migrate to the site
Day 8 Proliferation of fibroblasts seen with fresh collagen being laid down, angiogenesis, neovascularization, wound contraction seen Areas of fibroblast proliferation, new blood vessel formation, wound begin to contract
Day 12 Prominent wound contraction, collagen and fibrosis are increased prominent scar formation, cellularity reduced, all of which suggest good healing process Collagen is laid down significantly, inflammatory cells are reduced due to the healing process and presence of fibrous scar is noticed