Table S3.

Association of MIF promoter polymorphisms with violent suicide completers and controls

Polymorphism	Violent suicide (n=568)		Control (n=728)		P-valuea	Global P-valueb	OR (95% CI)	Power
	N	Frequency	N	Frequency
MIF-794CATT5–8
Genotype
55	82	0.144	105	0.144	0.995	0.313	1.001 (0.733–1.368)	0.050
56	220	0.387	251	0.345	0.114		1.201 (0.957–1.509)	0.329
57	70	0.123	95	0.130	0.697		0.937 (0.673–1.303)	0.066
66	105	0.185	158	0.217	0.153		0.818 (0.621–1.078)	0.309
67	79	0.139	93	0.128	0.551		1.103 (0.799–1.522)	0.088
77	12	0.021	26	0.036	0.122		0.583 (0.291–1.165)	0.387
Allele
CATT5	454	0.400	556	0.382	0.357	0.554	1.078 (0.919–1.263)	0.152
CATT6	509	0.448	660	0.453	0.791		0.979 (0.838–1.144)	0.057
CATT7	173	0.152	240	0.165	0.387		0.910 (0.736–1.126)	0.148
MIF-173G/C
Genotype
GG	355	0.625	451	0.620	0.840	0.542	1.024 (0.816–1.284)	0.054
GC	190	0.335	237	0.326	0.734		1.041 (0.825–1.315)	0.063
CC	23	0.040	40	0.055	0.230		0.726 (0.429–1.227)	0.250
Allele
G	900	0.792	1,139	0.782	0.539		1.061 (0.878–1.283)	0.094
C	236	0.208	317	0.218
Haplotype
MIFCATT5-173G	406.8	0.358	496.7	0.341	0.369	0.547	1.077 (0.916–1.268)	0.145
MIFCATT6-173G	494.8	0.436	640.9	0.440	0.812		0.981 (0.839–1.148)	0.055
MIFCATT7-173G	4.1	0.004	1.2	0.001	0.113		4.391 (0.573–33.63)	0.057
MIFCATT5-173C	47.2	0.042	59.3	0.041	0.915		1.021 (0.691–1.509)	0.052
MIFCATT6-173C	14.2	0.013	19.1	0.013	0.900		0.952 (0.477–1.901)	0.050
MIFCATT7-173C	168.9	0.149	238.8	0.164	0.286		0.890 (0.718–1.103)	0.184

Notes:

^aP-values were tested with the χ² test.

^bGlobal P-value was calculated by Fisher’s exact test or Cochran–Armitage test for trend, as appropriate.

Abbreviations: MIF, macrophage migration inhibitory factor; OR, odds ratio; CI, confidence interval.