Fig. 2.
Mean simulated digoxin plasma concentration time profiles (intravenous administration of 1 mg digoxin) for intermediate PBPK models used during development of the mechanistic kidney model. CLR defined by a single input value (136.1 ml/ min) based on the literature analysis (orange line) and CLR simulated using the mechanistic kidney model, accounting for only glomerular filtration (purple line), glomerular filtration and reabsorption (turquoise line), or glomerular filtration, reabsorption, and active secretion (blue line).