Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Simulated digoxin CLR and AUC0-∞ parameters in different virtual populations
Each value represents the mean of 100 simulated individuals taken from the virtual population provided with the SimCYP simulator after a single 0.75 mg i.v. dose.
| Population | Simulated CLR | % of healthy CLR | Simulated AUC0-∞ | % of healthy AUC0-∞ |
|---|---|---|---|---|
| ml/min | µg.min/ml | |||
| Healthy | 131.9 | 100 | 3.36 | 100 |
| Elderly | 90.7 | 69 | 5.12 | 152 |
| Moderate renal impairment | 65.9 | 50 | 5.68 | 169 |
| Severe renal impairment | 43.8 | 33 | 7.00 | 208 |
