Table 3.

Hcy editing, thiol aminoacylation, and peptide synthesis by AARSs [10,11].

AARS	Hcy Editing	Thiol-Binding Site Residue	Thiol Aminoacylation	Peptide Synthesis	References
Class I
MetRS	Yes	Asp359	Yes	Yes	[24,25,26,27,47,55,56,58,63,67]
LeuRS	Yes	Glu532	?	?	[25,26,58]
IleRS	Yes	Glu550	Yes	Yes	[25,26,58,63,64,66]
ValRS	Yes	Asp490	Yes	Yes	[58,64,65]
CysRS	No	?	Yes	?	[68]
ArgRS	No	?	Yes	Yes	[65]
Class II
SerRS	No	?	Yes	Yes	[38,63]
AspRS	No	?	Yes	Yes	[38,63]
LysRS	Yes	?	Yes	Yes	[29,38]

?—Not examined.