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Class I IleRS and ValRS, and Class II LysRS exhibit relaxed amino acid selectivity in the CoA-SH aminoacylation reaction.
| Amino Acid | IleRS, kcat/KM (min−1·M−1) | ValRS, kcat/KM (min−1·M−1) | LysRS, v (µM/h) |
|---|---|---|---|
| Isoleucine | 440,000 | 115 | 0.24 |
| Valine | 45,000 | 3300 | 0.67 |
| Leucine | 7700 | <5 | 2.7 |
| Threonine | 1200 | 1400 | 2.7 |
| Serine | 170 | <0.1 | |
| Alanine | 1300 | 500 | 1.7 |
| Lysine | 1.9 |
