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. 2017 Feb 25;13(3):327–338. doi: 10.7150/ijbs.17751

Figure 7.

Figure 7

HIF-1α was implicated in CP protecting pBVECs. CP (49 μg/ml) promoted the expression and nuclear relocation of HIF-1α in pBVECs in the model of OGD+LON (A). The loss of HIF-1α resulted in a decrease in cell viability (C) and increases in apoptotic and necrotic cells in CP-treated groups (B, D, E). Besides, the loss of HIF-1a impaired the inhibition of CP on Cyt-C release from mitochondria, showing increased cytoplastic Cyt-C and decreased mitochondrial Cyt-C (G-I). For apoptotic cell and necrotic cell, n = 6, mean ± SD; for western blot, n = 3, mean ± SD. * p<0.05; ** p<0.01; *** p<0.001.