Table 1.

MiRNAs involved in fibroblasts activation

Ref	Fibroblasts source	Differential expression MicroRNAs	Up-regulate/down-regulate in CAFs	methods to verify microRNA function		CAFs markers
(25)	human prostate cancer tissue	miR-133b	Up-regulate	Exogenous Overexpression of the miR-133b in primary normal prostate firoblasts		α-SMA, FAP, S100A4
	TGFβ induced HPFs
	IL-6 induced HPFs
(40)	breast cancer tissue	miR-146b-5p	down-regulate	ectopic expression of miR-146b-5p in CAFs		α-SMA
	normal breast tissue			inhibition of miR-146b-5p in breast stromal fibroblasts
	normal breast ajacent to cancer
(69)	mouse pancreat tissue	miRNA-155	Up-regulate	treated with mouse pancreat normal fibroblasts with pacreatic cancer cell derived microvesicles containing miRNA-155		α-SMA and FAP
(38)	gastric cancer tissue	miR-149	down-regulate	ectopic expression of miR-149 in CAFs		FAP
	gastric tissue			inhibition of miR-149 in NFs
(66)	esophageal cancer	miR-27a/b	Up-regulate	Normal fibroblasts from esophagus transfected with pre-miR-27a or pre-miR-27b		α-SMA and vimentin
	normal esophageal tissue
(24)	prostate cancer	miR-409	Up-regulate	Ectopic expression of miR-409 in normal prostate stromal fibroblasts		α-SMA
	normal prostate tissue
(70)	scirrhous type gastric cancer	miR-145	Up-regulate	transfected normal fibroblasts with pre-miR-145 and inhibit miR-145 expression in CAFs		α-SMA
	normal gastric tissue
(71)	esophageal cancer	miR-21	Up-regulate	HGF-1 fibroblasts transfected or inhibited with miR-21		S100A4
	HGF-1cell
(43)	MRC5 lung fibroblast cell		Up-regulate	Stable ectopic expression of miR-21 in immortalised MRC5 fibroblasts		α-SMA
	Primary colonic fibroblasts
(39)	benign prostatic hyperplasia	miR-210	Up-regulate	Exogenous Overexpression of the miR-133b in primary normal prostate firoblasts		α-SMA and collagen I