Table 3.
Predictors of course of MDD – Cox proportional hazard models, multivariate analysis
| Predictors of time to remission/recovery from index MDEa (n = 119) | HRb | 95% CI | P value |
|---|---|---|---|
| Marital status – single, separated, divorced or widowed | 0.53 | 0.32–0.88 | 0.01 |
| Length of index MDE – chronic | 0.45 | 0.26–0.76 | 0.003 |
| Comorbid anxiety disorder | 0.60 | 0.36–0.98 | 0.04 |
| Childhood Physical neglect | 0.43 | 0.22–0.86 | 0.02 |
| Predictors of time to recurrencesa (N = 65) | |||
| Age at onset of MDD | 0.97 | 0.911–1.03 | 0.29 |
| Length of index MDE – chronic | 0.48 | 0.17–1.33 | 0.16 |
| Number of previous MDEs ≥ 3 | 3.91 | 1.26–12.1 | 0.02 |
| Childhood Emotional neglect | 3.69 | 1.13–11.9 | 0.03 |
| Childhood Physical neglect | 1.15 | 0.38–3.41 | 0.81 |
Legend: MDE major depressive episode, MDD major depressive disorder aReference categories: Marital status: married or common-law; Length of index MDE: <2 years; Comorbid anxiety disorder: absent; Length of index MDE: <2 years; Number of previous MDEs: <3; Childhood neglect: absent bAdjusted for sex, age and length of follow-up