Table 2.
Logistic regression analysis of association between the polymorphisms and gastric cancer risk.
| Genotypes | Cases, n(%) | Controls, n(%) | OR (95% CI)a | p-Value |
|---|---|---|---|---|
| rs16901946 | ||||
| AA | 261(52.83) | 301(60.93) | Reference | |
| AG | 203(41.09) | 176(35.63) | 1.33(1.02,1.73) | 0.033 |
| GG | 30(6.07) | 17(3.44) | 2.07(1.11,3.86) | 0.023 |
| AG/GG | 233(47.17) | 193(39.07) | 1.39(1.08,1.79) | 0.011 |
| Additive model | 1.37(1.10,1.70) | 0.004 | ||
| rs13252298 | ||||
| AA | 236(47.77) | 209(42.31) | Reference | |
| AG | 215(43.52) | 235(47.57) | 0.81(0.62,1.06) | 0.120 |
| GG | 43(8.70) | 50(10.12) | 0.79(0.50,1.24) | 0.303 |
| AG/GG | 258(52.23) | 285(57.69) | 0.82(0.64,1.05) | 0.098 |
| Additive model | 0.85(0.70,1.04) | 0.113 | ||
| rs7463708 | ||||
| TT | 241(48.79) | 228(46.15) | Reference | |
| GT | 209(42.31) | 209(42.31) | 0.95(0.73,1.24) | 0.690 |
| GG | 44(8.91) | 57(11.54) | 0.73(0.47,1.12) | 0.151 |
| GT/GG | 253(51.21) | 266(53.85) | 0.90(0.70,1.16) | 0.428 |
| Additive model | 0.89(0.74,1.08) | 0.225 | ||
| rs7007694 | ||||
| TT | 264(53.44) | 272(55.06) | Reference | |
| CT | 199(40.28) | 198(40.08) | 1.04(0.80,1.35) | 0.760 |
| CC | 31(6.28) | 24(4.86) | 1.32(0.75,2.34) | 0.339 |
| CT/CC | 230(46.56) | 222(44.94) | 1.07(0.83,1.38) | 0.599 |
| Additive model | 1.09(0.88,1.34) | 0.441 | ||
| rs12543663 | ||||
| AA | 426(86.23) | 425(86.03) | Reference | |
| CA | 66(13.36) | 66(13.36) | 1.00(0.69,1.44) | 0.993 |
| CC | 2(0.40) | 3(0.61) | 0.68(0.11,4.17) | 0.680 |
| CA/CC | 68(13.77) | 69(13.97) | 0.99(0.69,1.42) | 0.945 |
| Additive model | 0.98(0.69,1.38) | 0.890 | ||
| rs1026411 | ||||
| GG | 186(37.65) | 188(38.06) | Reference | |
| GA | 230(46.56) | 218(44.13) | 1.05(0.79,1.38) | 0.753 |
| AA | 78(15.79) | 88(17.81) | 0.91(0.63,1.32) | 0.616 |
| GA/AA | 308(62.35) | 306(61.94) | 1.01(0.78,1.31) | 0.950 |
| Additive model | 0.97(0.81,1.16) | 0.725 | ||
| rs6983267 | ||||
| TT | 167(33.81) | 172(34.82) | Reference | |
| GT | 233(47.17) | 234(47.37) | 1.03(0.77,1.36) | 0.864 |
| GG | 94(19.03) | 88(17.81) | 1.08(0.75,1.55) | 0.677 |
| GT/GG | 327(66.19) | 322(65.18) | 1.04(0.80,1.35) | 0.776 |
| Additive model | 1.04(0.87,1.24) | 0.666 |
aAdjusted for age, gender, smoking, drinking, and Helicobacter pylori infection.