Table 2.
Meta-analysis Results for diarrhea.
| Compared genotype | Group | No. of studies | No. of participants | OR (95%CI) |
P | Test for heterogeneity | |
|---|---|---|---|---|---|---|---|
| P | I2 | ||||||
| TA6/7 vs. TA6/6 | All | 28 | 3435 | 1.56 (1.25-1.96) |
<0.001 | 0.175 | 19.9% |
| mCRC | 16 | 2563 | 1.60 (1.11-2.31) |
0.011 | 0.034 | 43.3% | |
| SCLC | 3 | 131 | 2.40 (0.74-7.74) |
0.144 | 0.208 | 36.3% | |
| mNSCLC | 3 | 235 | 0.92 (0.34-2.54) |
0.879 | 0.883 | 0.0% | |
| Asian | 18 | 2270 | 1.85 (1.37-2.50) |
<0.001 | 0.334 | 10.1% | |
| Caucasian | 9 | 1118 | 1.28 (0.91-1.80) |
0.117 | 0.136 | 35.3% | |
| Retrospective | 13 | 2123 | 1.70 (1.09-2.66) |
0.020 | 0.032 | 46.8% | |
| Prospective | 12 | 1090 | 1.69 (1.13-2.52) |
0.010 | 0.495 | 0.0% | |
| TA7/7 vs. TA6/6 | All | 17 | 2610 | 3.97 (1.88-8.38) |
<0.001 | 0.007 | 51.7% |
| mCRC | 14 | 1172 | 3.53 (1.54-8.09) |
0.003 | 0.004 | 57.5% | |
| Asian | 10 | 1805 | 8.98 (5.21-15.47) |
<0.001 | 0.152 | 32.0% | |
| Caucasian | 7 | 805 | 1.09 (0.56-2.13) |
0.807 | 0.259 | 22.3% | |
| Retrospective | 9 | 1737 | 4.84 (1.32-17.69) |
0.017 | <0.001 | 71.7% | |
| Prospective | 7 | 743 | 2.86 (1.30-6.30) |
0.009 | 0.555 | 0.0% | |
| TA6/7+7/7 vs. TA6/6 | All | 44 | 4868 | 2.18 (1.68-2.83) |
<0.001 | 0.003 | 40.8% |
| SCLC | 3 | 131 | 3.95 (1.42-11.01) |
0.009 | 0.115 | 53.8% | |
| mNSCLC | 4 | 321 | 1.24 (0.58-2.65) |
0.582 | 0.560 | 0.0% | |
| Advanced OC | 2 | 178 | 7.09 (2.91-17.26) |
<0.001 | 1.00 | 0.0% | |
| mCRC | 25 | 3477 | 1.96 (1.42-2.70) |
<0.001 | 0.005 | 47.3% | |
| Asian | 32 | 3607 | 2.74 (2.21-3.40) |
<0.001 | 0.132 | 22.2% | |
| Caucasian | 11 | 1214 | 1.39 (0.84-2.32) |
0.202 | 0.038 | 47.9% | |
| Retrospective | 16 | 2359 | 2.17 (1.36-3.49) |
0.001 | 0.001 | 62.0% | |
| Prospective | 24 | 2198 | 2.12 (1.62-2.79) |
<0.001 | 0.263 | 14.3% | |
| TA7/7 vs. TA6/7+TA6/6 | All | 24 | 3175 | 3.64 (2.01-6.58) |
<0.001 | <0.001 | 57.6% |
| SCLC | 2 | 64 | 19.90 (2.57-154.1) |
0.004 | 0.832 | 0.0% | |
| mCRC | 17 | 2656 | 3.16 (1.61-6.19) |
0.001 | <0.001 | 64.1% | |
| Asian | 13 | 1917 | 8.64 (4.14-18.04) |
<0.001 | 0.092 | 36.3% | |
| Caucasian | 10 | 1211 | 1.62 (1.03-2.53) |
0.035 | 0.188 | 27.8% | |
| Retrospective | 11 | 2003 | 2.06 (1.23-3.44) |
0.006 | 0.168 | 32.5% | |
| Prospective | 11 | 995 | 2.92 (1.64-5.21) |
<0.001 | 0.219 | 26.2% | |
mCRC, metastatic colorectal cancer; mNSCLC, metastatic non-small-cell lung cancer.