Table 2.

Application of the Classic Sex Hormone Paradigm to examine sex differences in elimination of perfluoroctanoic acid and in the expression of CYP2J5 in mouse kidney.

Procedure	Perfluoroctanoic acid clearance	CYP2J5 expression in mouse kidney
Citation	Kudo et al. (2002)	Ma et al. (2004)
Intact male	Much slower than female	Males have more protein
Treat intact male with estradiol	Inceased clearance	Reduced expression
Gonadectomized male	Clearance increased 14×	Reduced expression
Treat gonadectomized male with testosterone	Reverse the increase	Increased expression
Intact female	Rapid clearance	Low expression
Gonadectomize female	Greatly reduced clearance	Increased expression
Treat intact female with testosterone	Greatly reduced clearance	DHT raises female expression to male level
Treat gonadectomized female with estradiol	Reverse the reduction	Decreased expression