Table III.

Inflammatory markers in amniotic fluid, pregnancy outcome and placenta pathology results in patients with preterm prelabor rupture of membranes according to the results of amniotic fluid cultures and PCR/ESI-MS

	No inflammation/infection (n=18)	p* value	Sterile intra-amniotic inflammation (n=17)	p§ value	Microbial associated intra-amniotic inflammation (n=17)	p† value
GA at amniocentesis	31.5 (29.4 – 32.8)	0.02	28.5 (25.1 – 31.7)	0.04	24.8 (22.4 – 27.9)	<0.001
GA at delivery	33.7 (32.5 – 34.1)	0.006	31.8 (28 – 33)	0.003	25.1 (22.7 – 28.6)	<0.001
AF white blood cell count (cells/mm3)	1 (0 – 4)	<0.001	175 (21 – 395)	0.4	58 (12.5 – 442)	<0.001
AF glucose (mg/dL)	25 (13.5 – 31.7)	0.005	10 (10 −16)	0.4	13 (10 – 22)	0.02
AF IL-6 (ng/mL)	0.7 (0.5 – 1.1)	<0.001	12 (4.7 – 137)	0.1	40.4 (13.2 – 151.5)	<0.001
Interval amniocentesis to delivery	12 (1 – 22)	0.6	9 (1 – 22)	0.06	3 (1 – 4)	0.02
Composite neonatal morbidity	43.8 (7/16)	0.2	64.7 (11/17)	0.2	82.4 (14/17)	0.02
Acute placental inflammation	37.5 (6/16)	0.5	50 (8/16)	0.01	93.3 (14/15)	0.001
Acute histologic chorioamnionitis	37.5 (6/16)	0.5	50 (8/16)	0.01	93.3 (14/15)	0.001
Funisitis	25 (4/16)	0.4	37.5 (6/16)	0.1	66.7 (10/15)	0.02

IQR: interquartile range; AF: amniotic fluid; GA: gestational age; PCR: polymerase chain reaction; ESI-MS: electrospray ionization mass spectrometry

Data presented as median (interquartile) and percentage and (n); AF: amniotic fluid; IL: interleukin

^*Comparison between no inflammation and sterile intra-amniotic inflammation

^§Comparison between patients with sterile intra-amniotic inflammation and microbial-associated intra-amniotic inflammation

^†Comparison between patients with no inflammation/infection and microbial-associated intra-amniotic inflammation