Table 3.

17-Item Hamilton Scale for Depression: Differences between baseline and T1 (after 4 interventions) and T2 (4 weeks after treatment) in the hyperthermic bath group compared to the placebo group (intention-to-treat population;^a N = 36)

		T1				T2
	HTB Group (n = 17)	Placebo Group (n = 19)	P §	Cohen dc	HTB Group (n = 17)	Placebo Group (n = 19)	P §	Cohen dc
1HAM-Dtotal score b	4.35 (6.3)	1.21 (3.7)	0.037 *	0.62 [-0.05-1.29]	4.82 (7.3)	3.26 (5.7)	0.238	0.24 [-0.42-0.90]
2HAM-Dinsomnia b	0.94 (1.8)	0.16 (1.0)	0.053	0.55 [-0.11-1.22]	0.88 (1.7)	0.58 (1.8)	0.306	0.17 [-0.49-0.83]
2HAM-Dmood b	2.35 (3.2)	0.84 (2.2)	0.054	0.55 [-0.12-1.22]	2.82 (3.8)	1.74 (2.5)	0.156	0.33 [-0.33-0.99]
2HAM-Dsomatic b	0.59 (1.0)	0.21 (1.4)	0.182	0.31 [-0.35-0.97]	0.71 (1.4)	0.58 (1.4)	0.390	0.09 [-0.56-0.75]

Abbreviations: HTB hyperthermic baths, HAM-D Hamilton Scale for Depression

^aThe intention-to-treat analysis used last-observation-carried-forward

^bIndicates differences between HTB and placebo in the change from T0 to T1/T2 to each patient’s own end point for the change in depression rating

^cComputed as the difference between the means, M2 – M1, divided by the pooled standard deviation, sigma (σ_pooled) of both groups. [95% confidence interval]

Data are shown as mean and standard deviation (SD)

^§1-tailed t test

¹Primary outcome

²Secondary outcome

*P < .05