Table 2.

Screening strategies

	Kulasingam 2003 [27]	Sanders 2003 [28]	Goldie 2004 [29]	Taira 2004 [32]	Kulasingam 2007 [39]
Primary screening	CC	CC	CC/LBC	CC	CC
Compliance	100% (50–100%)	71% (60–80%)	100%	-	By age
Triage	CC	-	HPV DNA	-	-
Cytology
Sens/Spe	0.556(0.51–0.95)/ 0.957(0.80–0.97)	0.51(0.40–0.80)/ 0.97(0.95–0.98)	0.66(0.34–0.86)/ 0.97(0.88–0.99)	-	0.80(0.48–0.80)/ 0.95(0.90–0.99)
Price	$45 ($61–$75)	$81($61–$101)	$15–$51 ($12–75)		$58($29–$86)
HPV DNA
Sens/Spe	-	-	-	-	-
Price			$49 ($30–$200)
	Goldhaber-Fiebert 2008 [33]	Kim 2008 [31]	Coupe, de Melker 2009 [35]	Coupe, van Ginkel 2009 [36]	Kim 2009 [30]
Primary screening	CC/HPV DNA	CC	CC/HPV DNA	CC	CC
Compliance	-	-	80%	80% (20/70%)	-
Triage	HPV DNA/CC	HPV DNA (3y)	HPV DNA/CC	-	HPV DNA
Cytology
Sens/Spe	0.8(0.186–0.99)/0.95(0.87–0.996)	-	-	-	-
Price	$30($6–$87)
HPV DNA
Sens/Spe	0.83(0.70–0.85) / 0.93(0.79–0.94)	-	0.94/1	-	-
Price	$55($14–$217)
	Kim, Ortendahl 2009 [34]	Accetta 2010 [38]	Diaz 2010 [43]	Demarteau 2011 [41]	Burger 2012 [42]
Primary screening	CC/Combined	CC/HPV DNA	CC/Combined	CC	CC
Compliance	53% 1y, 17% 2y, 11% 3y, 15% 5y	70.90%	-	60% 3y (48%,1y-72%,5y)	100%
Triage	HPV DNA	HPV DNA/CC	HPV DNA	-	HPV DNA
Cytology
Sens/Spe	0.8/0.95	0.8/0.95	0.8/0.95	0.58–0.61 (0.46–0.73)	0.8/0.95
Price
HPV DNA
Sens/Spe	0.93/0.93	0.96/0.94	0.88/0.93	-	1/1
Price
	Coupe 2012 [37]	Tully 2012 [40]	Berkhof 2013 [44]
Primary screening	CC/HPV DNA	CC	CC/HPV DNA
Compliance	80% (40%)	-	-
Triage	-/CC	-	-
Cytology
Sens/Spe	-	0.58–0.85/0.962–0.974	-
Price	€52.80
HPV DNA
Sens/Spe	0.94/0.97	-	-/1
Price	€65.6

CC refers to the Pap smear test