Table 1. Physiological variables compared in neonatal piglets subjected to anesthesia alone (control) and anesthesia and surgery.
Body weight, post-natal age and duration of anesthesia were compared at baseline using an unpaired t-test. Physiological parameters were compared at baseline (BL) and at 1h intervals until termination, no statistically significant intergroup differences were observed using a repeated measures ANOVA.
| Physiological parameter | Time | Group mean (±SD) | |
|---|---|---|---|
| Anesthesia | Anesthesia + Surgery | ||
| Post-natal age (h) | - | 22.58 (8.61) | 24.92 (5.12) |
| Body weight (kg) | - | 1.85 (0.16) | 1.83 (0.13) |
| Duration of anaesthesia (h) | - | 6.63 (0.17) | 6.77 (0.27) |
| Heart rate (BPM) | BL | 140 (17) | 139 (13) |
| 1h | 150 (14) | 145 (18) | |
| 2h | 150 (15) | 157 (13) | |
| 3h | 148 (20) | 158 (14) | |
| 4h | 158 (23 | 161 (15) | |
| 5h | 168 (32) | 162 (17) | |
| 6h | 170 (23) | 160 (15) | |
| MABP mmHg | BL | 47.8 (5.6) | 42.0 (4.6) |
| 1h | 46.2 (6.5) | 41.7 (7.5) | |
| 2h | 45.9 (6.6) | 47.6 (8.5) | |
| 3h | 41.5 (7.8) | 41.2 (5.2) | |
| 4h | 43.7 (11.7) | 40.7 (3.7) | |
| 5h | 40.5 (5.6) | 39.5 (2.5) | |
| 6h | 39.6 (5.2) | 38.8 (3.3) | |
| Rectal temp °C | BL | 38.1 (1.2) | 37.9 (1.1) |
| 1h | 38.6 (1.1) | 37.6 (1.2) | |
| 2h | 38.4 (1.0) | 38.3 (1.1) | |
| 3h | 38.0 (1.0) | 38.5 (0.4) | |
| 4h | 38.2 (1.2) | 38.5 (0.6) | |
| 5h | 38.2 (1.0) | 38.4 (0.4) | |
| 6h | 38.5 (0.9) | 38.4 (0.4) | |
| PaO2 kPa | BL | 15.8 (8.8) | 18.2 (8.5) |
| 1h | 13.2 (4.9) | 16.6 (6.8) | |
| 2h | 15.2 (7.6) | 12.8 (6.6) | |
| 3h | 11.3 (3.7) | 11.9 (6.5) | |
| 4h | 12.8 (3.3) | 12.3 (6.7) | |
| 5h | 13.3 (4.0) | 12.9 (7.4) | |
| 6h | 11.5 (2.4) | 15.0 (8.2) | |
| PaCO2 kPa | BL | 4.82 (0.91) | 5.14 (1.64) |
| 1h | 6.47 (1.25) | 5.28 (1.99) | |
| 2h | 6.16 (1.60) | 5.32 (0.86) | |
| 3h | 6.25 (0.78) | 5.93 (1.18) | |
| 4h | 6.57 (1.30) | 5.90 (0.68) | |
| 5h | 5.97 (1.29) | 5.52 (1.02) | |
| 6h | 6.20 (1.60) | 5.38 (1.25) | |
| pH | BL | 7.5 (0.1) | 7.4 (0.2) |
| 1h | 7.4 (0.9) | 7.4 (0) | |
| 2h | 7.4 (0.1) | 7.4 (0) | |
| 3h | 7.4 (0) | 7.5 (0.1) | |
| 4h | 7.4 (0.1) | 7.4 (0.1) | |
| 5h | 7.4 (0.1) | 7.5 (0.1) | |
| 6h | 7.4 (0.1) | 7.5 (0.1) | |
| BE mmol/L | BL | 8 (4) | 6 (6) |
| 1h | 6 (4) | 5 (4) | |
| 2h | 6 (3) | 3 (3) | |
| 3h | 6 (3) | 5 (4) | |
| 4h | 6 (3) | 6 (4) | |
| 5h | 6 (4) | 6 (5) | |
| 6h | 6 (4) | 7 (5) | |
| Lactate mmol/L | BL | 3.6 (1.2) | 3.5 (1.7) |
| 1h | 3.3 (1.3) | 4.5 (1.9) | |
| 2h | 3.8 (2.0) | 5.4 (2.5) | |
| 3h | 3.9 (1.4) | 4.6 (2.2) | |
| 4h | 3.6 (1.5) | 4.0 (1.9) | |
| 5h | 3.4 (1.7) | 3.9 (1.8) | |
| 6h | 3.3 (1.5) | 3.5 (2.0) | |
| Glucose mmol/L | BL | 5.0 (1.3) | 5.4 (1.0) |
| 1h | 6.6 (1.1) | 6.3 (1.0) | |
| 2h | 7.3 (0.9) | 6.9 (1.0) | |
| 3h | 7.5 (1.0) | 7.0 (0.9) | |
| 4h | 7.2 (1.1) | 7.0 (0.8) | |
| 5h | 7.4 (1.2) | 7.2 (1.2) | |
| 6h | 9.6 (0.81) | 6.8 (0.7) | |
| Calcium mmol/L | BL | 1.4 (0.1) | 1.2 (0.5) |
| 1h | 1.5 (0.1) | 1.4 (0.1) | |
| 2h | 1.5 (0.1) | 1.5 (0.1) | |
| 3h | 1.4 (0.2) | 1.5 (0.1) | |
| 4h | 1.5 (0.1) | 1.5 (0.1) | |
| 5h | 1.4 (0.2) | 1.5 (0.1) | |
| 6h | 1.5 (0) | 1.5 (0.1) | |