Skip to main content
. 2017 Mar 29;12(3):e0174255. doi: 10.1371/journal.pone.0174255

Fig 1. The loss of SIRT6 caused defects in the development of tooth root and tooth eruption.

Fig 1

The Sirt6 KO mice had a smaller body size, thinner subcutaneous fat, and an accelerated mortality at about 3–4 weeks of age. (B) The dental phenotype of both Sirt6 WT and KO mice showed that both groups had approximately the same tooth contour. Tooth eruption, however, was significantly delayed in the KO mice, and the gingival tissue covering their tooth crown and their tooth root was shorter. (C) Micro-Computed Tomography revealed a reduction in the mandibular bone mineral density of the Sirt6 KO group. Hematoxylin and eosin (H&E) showed a tendency toward a similar delay in tooth eruption and tooth root development in Sirt6 KO group. (3W) (n = 6). Bars, as shown at the corner of the images.