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. 2017 Mar 29;12(3):e0174255. doi: 10.1371/journal.pone.0174255

Fig 2. Sirt6 deletion does not affect the development of the tooth germs.

Fig 2

(A) Micro-Computed Tomography testing revealed that the KO group differed from the WT group in several ways. The size of the tooth and mesial and distal roots were reduced in the KO group, and the diameter of the apical foramen of their distal root canal was wider. (B) H&E staining confirmed that there was no significant difference between the two groups with respect to in utero tooth germ morphogenesis. However, at or after DPN14, the first mandibular molar of the Sirt6 KO group suffered an obvious growth retardation and developmental delay when compared to the WT group (E13.5-2W) (n = 6). Bars, as shown at the corner of the images.