Table 2. GWIS interactions with P < 1x10^-5.

a. EA GWIS interaction P < 1x10-5
SNP	Locus	AA OR (CI)	AA P	EA OR	EA P	Minor Allele (AA/EA)
rs12285326	SAMSN1 (DHS)	1.42 (0.77, 1.72)	0.11	0.61(0.32, 0.62)	5.4x10-6	A/A
rs2822693	CAPRIN1 (Intergenic)	1.15 (0.92, 2.19)	0.49	0.45 (0.49, 0.76)	2.3x10-6	A/A
rs1108775	Intergenic	1.00 (0.72, 1.39)	0.99	1.55 (1.28, 1.87)	7.9x10-6	G/A
b. AA GWIS interaction P < 1x10-5
SNP	Locus	AA OR (CI)	AA P	EA OR	EA P	Minor Allele (AA/EA)
rs1856746	FCAMR (Intron)	2.96 (1.89, 4.64)	2.3x10-6	0.83 (0.68, 0.99)	0.048	A/G
rs2791713	FCAMR-PIGR (Intergenic)	3.00 (1.90, 4.73)	2.4x10-6	0.80 (0.66, 0.97)	0.02	G/A
rs291096	PIGR (V183V)	2.97 (1.88, 4.67)	2.7x10-6	0.85 (0.77, 1.02)	0.09	A/G
rs17366136	Intergenic	2.47 (1.66, 3.68)	8.1x10-6	0.86 (0.71, 1.04)	0.12	A/A
rs11012265	Intergenic	0.46 (0.33, 0.65)	9.1x10-6	1.01 (0.83, 1.21)	0.95	A/A

We observed three suggestive interactions in the EA GWIS (a) and five suggestive interactions in the AA GWIS (b) two of which replicated: rs1856746 and rs2791713. Rs1108775, rs17366136 and rs11012265 were all located in intergenic regions not near any annotated gene. Genotypes were coded according to the number of copies of the minor allele. BP = base pair location; CI = 95% confidence interval; DHS = DNAse I hypersensitivity site; OR = odds ratio for interaction from cumulative link model; SNP = SNP involved in the SNP-traffic exposure interaction