Table 2. Results of the genome-wide association study for pulmonary tuberculosis in the KARE Study (P < 1×10−5).
| Gene | Chr. | SNP | Function | Modela | N/R | NN/NR/RRb | RAF | MLRc | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases/Controls | OR (95% CI) | P | ||||||
| FARP1 | 13q32.2 | rs3825435 | intron | A | T/C | 303/144/20 | 996/298/18 | 0.20/0.13 | 1.69 (1.38–2.07) | 5.3×10−7 |
| OXR1 | 8q23.1 | rs3110431 | intron | D | T/C | 180/223/54 | 668/519/126 | 0.37/0.29 | 1.70 (1.37–2.12) | 2.1×10−6 |
| CLIC5 | 6p12.3 | rs9381416 | intron | A | A/C | 76/216/174 | 320/640/353 | 0.61/0.51 | 1.44 (1.23–1.67) | 4.0×10−6 |
| KLHL36 | 16q24.1 | rs2326344 | intergenic | A | G/T | 203/214/50 | 726/506/81 | 0.34/0.25 | 1.48 (1.25–1.75) | 4.9×10−6 |
| IGSF11 | 3q13.3 | rs571110 | intergenic | R | G/A | 258/150/47 | 766/463/59 | 0.27/0.23 | 2.56 (1.70–3.85) | 6.9×10−6 |
| SRBD1 | 2p21 | rs17394081 | intron | D | C/T | 423/43/1 | 1257/55/1 | 0.05/0.02 | 2.61 (1.72–3.98) | 7.9×10−6 |
Abbreviations: Chr., chromosome; N/R, non-risk/risk allele; OR, odds ratio; MLR, multiple logistic regression; RAF, risk allele frequency; SNP, single nucleotide polymorphism
a The genetic model that showed the most significant evidence for association with PTB: A, additive; R, recessive.
b NN/NR/RR, the numbers of cases and controls with non-risk homozygote/heterozygote/risk homozygote genotypes, respectively.
c ORs and P values were estimated from the MLR model adjusted for age, sex, and BMI.