Table 3. Ten replicated SNPs associated with PTB in the KARE and HEXA Studies.

Gene	Chr.	SNP	Function	Modela	N/Rb	KARE		HEXA		Joint Analysis
						OR (95% CI)c	P	OR (95% CI)c	P	OR (95% CI)c	P
CDCA7	2q31.1	rs7594926	intergenic	D	G/A	1.59 (1.22–2.08)	7.6×10−4	1.64 (1.05–2.56)	0.030	1.54 (1.23–1.89)	1.4×10−4
GBE1	3p12.2	rs2307058	intron	R	C/T	1.75 (1.31–2.33)	1.4×10−4	1.60 (1.02–2.50)	0.040	1.63 (1.29–2.05)	3.4×10−5
GADL1	3p23	rs9682385	intergenic	A	G/A	1.34 (1.14–1.58)	5.4×10−4	1.45 (1.11–1.91)	0.007	1.31 (1.15–1.50)	7.9×10−5
SPATA16	3q26.31	rs9840514	intergenic	R	T/C	1.79 (1.27–2.50)	9.5×10−4	1.96 (1.16–3.23)	0.011	1.96 (1.16–3.23)	5.4×10−5
C6orf118	6q27	rs9365798	intergenic	D	T/C	1.61 (1.27–2.04)	7.1×10−5	1.49 (1.02–2.17)	0.038	1.59 (1.32–1.92)	2.1×10−6
KIAA1432	9p24.1	rs4348560	intron	R	G/A	1.79 (1.28–2.50)	6.3×10−4	1.75 (1.04–2.94)	0.034	1.69 (1.30–2.22)	1.3×10−4
DMRT2	9p24.3	rs10738171	intergenic	A	C/T	1.33 (1.12–1.57)	8.9×10−4	1.34 (1.03–1.75)	0.029	1.30 (1.14–1.49)	1.3×10−4
CTR9	11p15.3	rs9787961	Near 5’-UTR	R	C/G	1.67 (1.26–2.21)	3.9×10−4	1.83 (1.17–2.85)	0.008	1.64 (1.30–2.06)	2.3×10−5
CCDC67	11q21	rs3019221	intron	A	G/C	1.61 (1.25–2.07)	2.3×10−4	1.50 (1.00–2.23)	0.048	1.56 (1.27–1.91)	2.1×10−5
CDH13	16q23.3	rs12716963	intron	D	C/T	1.54 (1.19–1.96)	7.7×10−4	1.72 (1.12–2.83)	0.012	1.56 (1.27–1.92)	2.6×10−5

Abbreviations: Chr., chromosome; CI, confidence interval; HEXA, Health Examinees Study; KARE, Korea Association Resource Study; OR, odds ratio.

^a The genetic models that showed the most significant evidence for association with PTB: A, additive; D, dominant; R, recessive.

^b N/R, non-risk/risk allele

^c ORs and P values were estimated from the multiple logistic regression model adjusted for age, sex, and BMI.