Table 4. Replication of risk models for pulmonary tuberculosis.
| Risk model | SNP | AUC (95% CI)a | |||||
|---|---|---|---|---|---|---|---|
| Pdiff < 1×10−4b | N | wGRSc | wnGRS1d | wnGRS2e | wnGRS3f | wnGRS4g | |
| KARE | 0.636 (0.607–0.665) | ||||||
| Nongenetic model | Cases/Controls, N | 467/1313 | 463/1308 | 463/1308 | 463/1305 | ||
| 0.630 (0.602–0.659) | 0.627 (0.598–0.657) | 0.634 (0.604–0.663) | 0.633 (0.603–0.662) | ||||
| Combined model | Cases/Controls, N | 467/1313 | 463/1305 | 463/1308 | 463/1305 | ||
| 0.690 (0.663–0.718) | 0.684 (0.656–0.712) | 0.692 (0.665–0.720) | 0.687 (0.659–0.715) | ||||
| HEXA | 0.639 (0.587–0.692) | ||||||
| Nongenetic model | Cases/Controls, N | 179/500 | 177/498 | 151/498 | 141/498 | ||
| 0.693 (0.650–0.736) | 0.689 (0.643–0.735) | 0.770 (0.726–0.814) | 0.780 (0.734–0.825) | ||||
| Combined model | Cases/Controls, N | 170/490 | 168/490 | 142/490 | 132/490 | ||
| 0.739 (0.697–0.781) | 0.736 (0.692–0.780) | 0.799 (0.758–0.841) | 0.808 (0.765–0.851) |
Abbreviations: AUC, area under the receiver operating curve; CI, confidence interval; wGRS weighted genetic risk score; wnGRS, weighted non-genetic risk score.
a AUCs and P values were estimated for ROC analyses
b Pdiff < 1×10−4, AUCs of the three risk score models, wGRS, wnGRS, and wGRS+wnGRS, were significantly different from each other at P < 0.0001.
c wGRS, the weighted genetic risk score model composed of the ten replicated SNPs.
d wGRS+wnGRS1, the combined model of wGRS model composed of 10 validated SNPs plus wnGRS1 comprised of age, sex, BMI.
e wnGRS2 was comprised of wnGRS1 plus cigarette smoking, and alcohol consumption.
f wnGRS3 was comprised of wnGRS1 plus cigarette smoking, SBP and Hb.
g wnGRS4 was comprised of wnGRS3 plus alcohol consumption, DBP, and BUN.