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. 2016 Apr 27;59(10):4625–4636. doi: 10.1021/acs.jmedchem.5b02001

Figure 2.

Figure 2

5′-Hydroxyl has little effect on affinity. The heteroatoms and stereochemistry highlighted in red are important for affinity to HSP70 and could not be replaced by hydrogen or CH or the stereochemistry changed.