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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Curr Top Dev Biol. 2016 Sep 28;122:195–221. doi: 10.1016/bs.ctdb.2016.08.008

Fig. 2.

Fig. 2

Transcriptional regulation by TBX5. TBX5, through its interactions with other cardiac transcription factors, such as GATA4 and NKX2-5, and the BAF chromatin-remodeling complex drive active transcription of target cardiac genes in regions of open chromatin (top panel). TBX5, through its interactions with the NuRD complex and other transcriptional repressors, such as SALL4, remodel chromatin to a closed state, which represses gene expression of noncardiac genes (bottom panel). Reprinted from Boogerd, C. J., & Evans, S. M. (2016). TBX5 and NuRD divide the heart. Developmental Cell, 36(3), 242–244, with permission from Elsevier.