FIG 6 .

Regulatory network in integrons. Representation of cassette dynamics, namely, cassette storage in SCIs, cassette mobilization from SCIs to MIs, and cassette excision, shuffling, and dissemination in MIs is shown in blue. Representation of the regulatory network is shown in red. Toxin-antitoxin (TA) systems stabilize cassette arrays in SCIs and supercoiling, replication (lagging strand template), and conjugation favor attC site folding and cassette dynamics. Representation of the connections between integrons and bacterial physiology is shown in green. Conjugation, competence, and antibiotics induce the SOS response and integrase expression, and carbon sources initiate catabolite repression and integrase expression.