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Plasma endothelin‐1 changes from baseline according to time and venous congestion (VC) dose. Change is computed as endothelin‐1 differences between each time point and baseline levels in the test arm; 30 mmHg data at 180 min in the test arm are based on a sample of 18 subjects; 15 mmHg data at 60 min in the control arm are based on a sample of 19 subjects.
