Figure 6.

Select gait indices invoking neuromuscular function. Mice were evaluated at 25 weeks. (A) Forepaw placement angle was significantly more open in Bla/J mice compared to WT mice, differences that were sustained during uphill and downhill walking. (B) Hind paw placement angle during full stance was more open during horizontal walking at 24 cm/s and 40 cm/s. Hind paw placement angle was less adaptive in Bla/J mice to changes in walking conditions. (C) Hind limb shared stance was significantly briefer in Bla/J mice than in WT mice, suggesting muscle weakness. This characteristic was more apparent in downhill walking than during uphill walking.