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. 2017 Mar 21;5(6):e13199. doi: 10.14814/phy2.13199

Figure 2.

Figure 2

Effect of acute fructose stimulation on duodenal and colonic EC cells. (A) Time course of Ca2+ (i) changes in duodenal EC cells in response to fructose, shown as % change from baseline. Dotted lines indicate SEM. Arrow indicates time of stimulus addition (n = 3–9 mice). (B) AUC of Ca2+ (i) in duodenal EC cells. *P < 0.05 (n = 3–9 mice). (C) Release of 5‐HT from duodenal EC cells in culture following 20 min exposure to fructose (Fruc) or α‐MG. ***P < 0.001 (n = 4–9 mice). (D) Time course of Ca2+ (i) changes in colonic EC cells in response to fructose, shown as % change from baseline. Arrow indicates time of stimulus addition (n = 4–8 mice). (E) AUC of Ca2+ (i) in colonic EC cells. ***P < 0.001 (n = 4–8 mice). (F) Release of 5‐HT from colonic EC cells in culture following 20 min exposure to fructose (Fruc) or α‐MG. *P < 0.05 (n = 3–9 mice). Data are shown as mean ± SEM. AUC, area under the curve.